CyFlow™ CD11b Low Endotoxin
| Alternative Name: | Mac-1 |
| Antibody: | Yes |
| Antigen: | CD11b |
| Application: | Flow cytometry, Functional assays, Immunohistochemistry (frozen sections), Immunoprecipitation |
| Clonality: | monoclonal |
| Clone: | M1/70 |
| Field of Interest: | Immunophenotyping, MHC |
| Format/Fluorochrome: | Low Endotoxin |
| Isotype: | IgG2b |
| Regulatory Status: | RUO |
| Source Species: | Rat |
| Target Species: | Human, Mouse, Non-Human Primates, Rabbit |
| Product number: | AX566986 |
For Research Use Only
| Concentration Unit | mg/mL |
| Concentration | 1 |
| Quantity | 0.1 mg |
| Volume | 0.1 mL |
| Immunogen | B10 mouse spleen cells enriched for T cells |
| Background Information | CD11b (integrin αM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with CD18 (integrin β2 subunit); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component. |
| Storage Buffer | The reagent is provided in azide-free phosphate buffered saline (PBS) solution, pH ≈7.4; 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
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