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CyFlow™ CD123 PerCP-Cy5.5

CyFlow™ CD123 PerCP-Cy5.5
Alternative Name: IL-3Ra , IL3R
Antibody: Yes
Antigen: CD123
Application: Flow cytometry
Clonality: monoclonal
Clone: 6H6
Emission Maximum: 695 nm
Excitation Maximum: 482 nm
Field of Interest: Immunophenotyping, Signaling
Format/Fluorochrome: PerCP-Cy5.5
Isotype: IgG1
Laser: Blue , Green
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: CY718949

For Research Use Only

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Description Documentation TDS & SDS
Description
Quantity 100 tests Volume 0.4 mL Immunogen IL3 receptor α chain expressed on the... more
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CyFlow™ CD123 PerCP-Cy5.5

Quantity100 tests
Volume0.4 mL
ImmunogenIL3 receptor α chain expressed on the surface of transiently transfected COS cells
Background InformationCD123 is the α chain of interleukin 3 receptor (IL-3R α). This subunit heterodimerizes with the interleukin 3 receptor β chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the β subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signaling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Sun Q, Woodcock JM, Rapoport A, Stomski FC, Korpelainen EI, Bagley CJ, Goodall GJ, Smith WB, Gamble JR, Vadas MA, Lopez AF: Monoclonal antibody 7G3 recognizes the N‑terminal domain of the human interleukin‑3 (IL‑3) receptor alpha‑chain and functions as a specific IL‑3 receptor antagonist. Blood. 1996 Jan 1; 87(1):83‑92. < PMID: 8547680 > | Herling M, Teitell MA, Shen RR, Medeiros LJ, Jones D: TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin. Blood. 2003 Jun 15; 101(12):5007‑9. < PMID: 12576313 > | Martín-Gayo E, Sierra-Filardi E, Corbí AL, Toribio ML: Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development. Blood. 2010 Jul 1; 115(26):5366‑75. < PMID: 20357241 >

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Technical Data Sheet