CyFlow™ CD7 FITC
| Alternative Name: | gp40 |
| Antigen: | CD7 |
| Application: | Flow cytometry |
| Clonality: | monoclonal |
| Clone: | 124-1D1 |
| Emission Maximum: | 518 nm |
| Excitation Maximum: | 490 to 495 nm |
| Field of Interest: | Immunophenotyping |
| Format/Fluorochrome: | FITC |
| Isotype: | IgG1 |
| Laser: | Blue |
| Regulatory Status: | CE IVD |
| Source Species: | Mouse |
| Target Species: | Human |
| Product number: | BZ652898 |
CE IVD
| HLDA Workshop | HLDA IV—WS Code T155 |
| Concentration Unit | µg/mL |
| Concentration | 80 |
| Quantity | 100 tests |
| Volume | 1.0 mL |
| Immunogen | Not available |
| Background Information | CD7 (gp40) is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 co-stimulation can induce cytokine secretion and modulate cellular adhesion. A ligand of CD7, epithelial cell secreted protein K12, is produced in thymus to regulate thymocyte signaling and cytokine release. In lung microvascular endothelial cells CD7 serves as an IgM Fc receptor. |
| Antigen Distribution | CD7 (gp40) is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 co-stimulation can induce cytokine secretion and modulate cellular adhesion. A ligand of CD7, epithelial cell secreted protein K12, is produced in thymus to regulate thymocyte signaling and cytokine release. In lung microvascular endothelial cells CD7 serves as an IgM Fc receptor. |
| Usage | CE IVD usage Placeholder |
| Storage Buffer | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
| Pelegri C, Castell M, Serra M, Rabanal M, Rodríguez‐Palmero M, Castellote C, Franch A: Prevention of adjuvant arthritis by the W3/25 anti‐CD4 monoclonal antibody is associated with a decrease of blood CD4+ CD45RChigh T cells. Clin Exp Immunol. 2001 Sep 1; 125(3):470‐7. < PMID: 11531956 > | Vicario M, Amat C, Rivero M, Moretó M, Pelegrí C: Dietary glutamine affects mucosal functions in rats with mild DSS‐induced colitis. J Nutr. 2007 Aug 1; 137(8):1931‐7. < PMID: 17634266 > | Van Dongen JJ, Lhermitte L, Böttcher S, Almeida J, Van der Velden VH, Flores‐Montero J, Rawstron A, Asnafi V, Lecrevisse Q, Lucio P, Mejstrikova E: EuroFlow antibody panels for standardized n‐dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes. Leukemia. 2012 Sep 1; 26(9):1908‐75. < PMID: 22552007 > | Preston SG, Majtán J, Kouremenou C, Rysnik O, Burger LF, Cruz AC, Guzman MC, Nunn MA, Paesen GC, Nuttall PA, Austyn JM: Novel immunomodulators from hard ticks selectively reprogramme human dendritic cell responses. PLoS Pathog. 2013 Jun 27; 9(6):e1003450. < PMID: 23825947 >