CyFlow™ CD8 Pacific Orange™
| Antigen: | CD8 |
| Application: | Flow cytometry |
| Clonality: | monoclonal |
| Clone: | MEM-31 |
| Emission Maximum: | 551 nm |
| Excitation Maximum: | 400 nm |
| Field of Interest: | Immunophenotyping |
| Format/Fluorochrome: | Pacific Orange™ |
| Isotype: | IgG2a |
| Laser: | Violet |
| Regulatory Status: | CE IVD |
| Source Species: | Mouse |
| Target Species: | Human |
| Product number: | CB402987 |
CE IVD
| HLDA Workshop | HLDA III—WS Code T 575 |
| Concentration Unit | µg/mL |
| Concentration | 20 |
| Quantity | 100 tests |
| Volume | 1.0 mL |
| Immunogen | Crude thymus membrane fraction |
| Background Information | The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as α/β heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as α/α homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8 β level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 α-β but not α-α dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling. |
| Antigen Distribution | CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as α/β heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as α/α homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. |
| Usage | CE IVD usage Placeholder |
| Storage Buffer | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
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