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CyFlow™ CD41 APC

CyFlow™ CD41 APC
Alternative Name: gpIIb
Antigen: CD41
Application: Flow cytometry
Clonality: monoclonal
Clone: MEM-06
Emission Maximum: 660 nm
Excitation Maximum: 650 nm
Field of Interest: Immunophenotyping
Format/Fluorochrome: APC
Isotype: IgG1
Laser: Red
Regulatory Status: CE IVD
Source Species: Mouse
Target Species: Human
Product number: BA233808

CE IVD

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Description
HLDA Workshop HCDM/HLDA 10 Concentration Unit µg/mL Concentration 40 Quantity... more
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CyFlow™ CD41 APC

HLDA WorkshopHCDM/HLDA 10
Concentration Unitµg/mL
Concentration40
Quantity100 tests
Volume1.0 mL
ImmunogenLeukocytes of a patient suffering from LGL-type leukemia
Background InformationCD41 (GPIIb; platelet glycoprotein IIb) is composed of two subunits (120 kDa GPIIb α and 23 kDa GPIIb β) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
Antigen DistributionCD41 (GPIIb) is a transmembrane glycoprotein (integrin family) composed of two chains GPIIb α (heavy chain; 120 kDa) and GPIIb β (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes. CD41 interacts with CD61 in the presence of calcium to form a functional adhesive protein receptor.
UsageCE IVD usage Placeholder
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Debili N, Robin C, Schiavon V, Letestu R, Pflumio F, Mitjavila-Garcia MT, Coulombel L, Vainchenker W: Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates. Blood. 2001 Apr 1; 97(7):2023‑30. < PMID: 11264167 > | Mitjavila-Garcia MT, Cailleret M, Godin I, Nogueira MM, Cohen-Solal K, Schiavon V, Lecluse Y, Le Pesteur F, Lagrue AH, Vainchenker W: Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells. Development. 2002 Apr; 129(8):2003‑13. < PMID: 11934866 > | Ferkowicz MJ, Starr M, Xie X, Li W, Johnson SA, Shelley WC, Morrison PR, Yoder MC: CD41 expression defines the onset of primitive and definitive hematopoiesis inthe murine embryo. Development. 2003 Sep; 130(18):4393‑403. < PMID: 12900455 > | Zhang J, Varas F, Stadtfeld M, Heck S, Faust N, Graf T: CD41‑YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation. Exp Hematol. 2007 Mar; 35(3):490‑499. < PMID: 17309829 >

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