CyFlow™ CD79a PE
| Alternative Name: | IgA , MB-1, MB1 |
| Antigen: | CD79a |
| Application: | Flow cytometry |
| Clonality: | monoclonal |
| Clone: | HM57 |
| Emission Maximum: | 576 nm |
| Excitation Maximum: | 496 nm, 565 nm |
| Field of Interest: | Immunophenotyping |
| Format/Fluorochrome: | PE |
| Isotype: | IgG1 |
| Laser: | Blue , Green, Yellow |
| Regulatory Status: | CE IVD |
| Source Species: | Mouse |
| Target Species: | Human |
| Product number: | CA983512 |
CE IVD
| HLDA Workshop | HLDA V—WS Code BC cB018 HLDA VI—WS Code BP 193 HLDA VI—WS Code BP 89 HLDA VI—WS Code B B103 HLDA VI—WS Code B CD79.4 |
| Concentration Unit | µg/mL |
| Concentration | 70 |
| Quantity | 100 tests |
| Volume | 1.0 mL |
| Immunogen | Synthetic peptide corresponding to amino acids 202-216 of human CD79a |
| Background Information | CD79a (Ig α, MB1) forms disulfide-linked heterodimer with CD79b (Ig β, B29). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with λ5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling. |
| Antigen Distribution | CD79a (IgA, MB-1, MB1) is a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms. It forms disulfide-linked heterodimer with CD79b (IgB, B29). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). |
| Usage | CE IVD usage Placeholder |
| Storage Buffer | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
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