CyFlow™ CD123 PerCP-Cy5.5
| Alternative Name: | IL-3Ra , IL3R |
| Antigen: | CD123 |
| Application: | Flow cytometry |
| Clonality: | monoclonal |
| Clone: | 6H6 |
| Emission Maximum: | 695 nm |
| Excitation Maximum: | 482 nm |
| Field of Interest: | Immunophenotyping, Signaling |
| Format/Fluorochrome: | PerCP-Cy5.5 |
| Isotype: | IgG1 |
| Laser: | Blue , Green |
| Regulatory Status: | CE IVD |
| Source Species: | Mouse |
| Target Species: | Human |
| Product number: | AX349290 |
CE IVD
| Concentration Unit | µg/mL |
| Concentration | 50 |
| Quantity | 100 tests |
| Volume | 1.0 mL |
| Immunogen | IL3 receptor α chain expressed on the surface of transiently transfected COS cells |
| Background Information | CD123 is the α chain of interleukin 3 receptor (IL-3R α). This subunit heterodimerizes with the interleukin 3 receptor β chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the β subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signaling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step. |
| Antigen Distribution | CD123 (IL-3Ra, IL3R) is the α chain of interleukin 3 receptor. This subunit heterodimerizes with the interleukin 3 receptor β chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the β subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signalling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step. |
| Usage | CE IVD usage Placeholder |
| Storage Buffer | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
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