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CyFlow™ CD157 PE

CyFlow™ CD157 PE
Alternative Name: BP-3/IF7, BST1, cADPr hydrolase 2, Mo5
Antigen: CD157
Application: Flow cytometry
Clonality: monoclonal
Clone: SY11B5
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Field of Interest: Immunophenotyping
Format/Fluorochrome: PE
Isotype: IgG1
Laser: Blue , Green, Yellow
Regulatory Status: CE IVD
Source Species: Mouse
Target Species: Human
Product number: CN417474

CE IVD

Description Documentation TDS & SDS
Description
Concentration Unit µg/mL Concentration 70 Quantity 100 tests Volume 1.0 mL... more
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CyFlow™ CD157 PE

Concentration Unitµg/mL
Concentration70
Quantity100 tests
Volume1.0 mL
ImmunogenHuman CD157
Background InformationCD157 (cADPr hydrolase 2, BST1, BP-3/IF7, Mo5) is a GPI-anchored ectoenzyme possessing ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activity. It uses NAD and cADP-ribose as substrates. CD157 is expressed on granulocytes, monocytes, macrophages, follicular dendritic cells, bone marrow stromal cells and human umbilical cord vein endothelial cells. In case of rheumatoid arthritis the expression is often higher and it is also differentially expressed in the myeloid leukemias. It may also have a signaling role.
Antigen DistributionCD157 (cADPr hydrolase 2, BST1, BP-3/IF7, Mo5) is a GPI-anchored ectoenzyme possessing ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activity and with structural and functional similarities to CD38. It uses NAD and cADP-ribose as substrates. CD157 is expressed on granulocytes, monocytes, macrophages, follicular dendritic cells, bone marrow stromal cells and human umbilical cord vein endothelial cells.
UsageCE IVD usage Placeholder
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Sutherland R, Acton E, Keeney M, Borowitz M, Richards S, Fletcher M, Whitby L, Barnett D, Illingworth A: Recommended antibody clones and conjugates suitable for high-sensitivity flow cytometric detection of PNH Red (RBC) and White (WBC) Blood Cells. Cytometry Part B: Clinical Cytometry. 2013 Nov 1; 84(6):422-3. < No PMID > | Sutherland DR, Acton E, Keeney M, Davis BH, Illingworth A: Use of CD in FLAER‐based assays for high‐sensitivity PNH granulocyte and PNH monocyte detection. Cytometry Part B: Clinical Cytometry. 2014 Jan 1; 86(1):44-55. < PMID: 23922226 > | Marinov I, Kohoutová M, Tkáčová V, Pešek A, Čermák J, Cetkovský P: Clinical relevance of CD for rapid and cost‐effective simultaneous evaluation of PNH granulocytes and monocytes by flow cytometry. Int J Lab Hematol. 2015 Apr; 37(2):231-7. < PMID: 24963875 > | Arriga R, Caratelli S, Coppola A, Spagnoli GC, Venditti A, Amadori S, Lanzilli G, Lauro D, Palomba P, Sconocchia T, Del Principe MI: Enhancement of anti-leukemia activity of NK cells in vitro and in vivo by inhibition of leukemia cell-induced NK cell damage. Oncotarget. 2016 Jan 12; 7(2):2070. < PMID: 26655503 > | Marinov I, Illingworth AJ, Benko M, Sutherland DR: Performance characteristics of a non‐FLAER‐based PNH assay for simultaneous evaluation of PNH neutrophils and PNH monocytes by flow cytometry, following published PNH guidelines. Cytometry B Clin Cytom. 2016 Jun 13; < PMID: 27294344 >

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