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CyFlow™ MPO APC

CyFlow™ MPO APC
Antigen: Myeloperoxidase
Application: Flow cytometry
Clonality: monoclonal
Clone: MPO421-8B2
Emission Maximum: 660 nm
Excitation Maximum: 650 nm
Field of Interest: Immunophenotyping, Others
Format/Fluorochrome: APC
Isotype: IgG1
Laser: Red
Regulatory Status: CE IVD
Source Species: Mouse
Target Species: Human
Product number: CE766245

CE IVD

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Description
Concentration Unit µg/mL Concentration 100 Quantity 100 tests Volume 1.0 mL... more
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CyFlow™ MPO APC

Concentration Unitµg/mL
Concentration100
Quantity100 tests
Volume1.0 mL
ImmunogenHuman myeloperoxidase
Background InformationMyeloperoxidase (MPO) is a heme enzyme that is localized in azurophilic (primary) granules of myeloid cells and its synthesis occurs at an early stage of differentiation. The mature myeloperoxidase is a tetramer composed of two light (12 kDa) and two heavy (60 kDa) chains. This enzyme uses hydrogen peroxide to oxidize numerous substrates, including serotonin, melatonin or chloride, to produce reactive free radicals that contribute to immune reactions of myeloid cells against pathogens. Myeloperoxidase functions not only in host defense by mediating efficient microbial killing but also can contribute to progressive tissue damage in chronic inflammatory states such as atherosclerosis or acute pancreatitis.
Antigen DistributionMyeloperoxidase (MPO) is a heme enzyme that is localized in azurophilic (primary) granules of myeloid cells and its synthesis occurs at an early stage of differentiation. The mature myeloperoxidase is a tetramer composed of two light (12 kDa) and two heavy (60 kDa) chains.
UsageCE IVD usage Placeholder
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Anne H van der Spek, Flavia F Bloise, Wikky Tigchelaar, Monica Dentice, Domenico Salvatore, Nicole N van der Wel, Eric Fliers, Anita Boelen: The Thyroid Hormone Inactivating Enzyme Type 3 Deiodinase is Present in Bactericidal Granules and the Cytoplasm of Human Neutrophils. 2016 Aug; 157(8):3293‐3305. < PMID: 27355490 > | Antje Vogelgesang, Claudia Lange, Lara Blümke, Georg Laage, Sarah Rümpel, Sönke Langner, Barbara M Bröker, Alexander Dressel, Johanna Ruhnau: Ischaemic stroke and the recanalization drug tissue plasminogen activator interfere with antibacterial phagocyte function. JNeuroinflammation. 2017 Jul 21; 14:140. < PMID: 28732504 >

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