CyFlow™ CD19 PE-DyLight™ 594
| Alternative Name: | B4 |
| Antigen: | CD19 |
| Application: | Flow cytometry |
| Clonality: | monoclonal |
| Clone: | LT19 |
| Emission Maximum: | 618 nm |
| Excitation Maximum: | 593 nm |
| Field of Interest: | Immunophenotyping |
| Format/Fluorochrome: | PE-DyLight™ 594 |
| Isotype: | IgG1 |
| Laser: | Blue , Green, Yellow |
| Regulatory Status: | CE IVD |
| Source Species: | Mouse |
| Target Species: | Human |
| Product number: | AQ335127 |
CE IVD
| HLDA Workshop | HCDM/HLDA 10 |
| Concentration Unit | µg/mL |
| Concentration | 40 |
| Quantity | 100 tests |
| Volume | 1.0 mL |
| Immunogen | Daudi human Burkitt lymphoma cell line |
| Background Information | CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity. |
| Antigen Distribution | CD19 (B4) is a 95 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on B lymphocytes and follicular dendritic cells; it is lost on plasma cells. |
| Usage | CE IVD usage Placeholder |
| Storage Buffer | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
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