CyFlow™ CD117 APC-Cy7
| Alternative Name: | c-kit , SCFR |
| Antigen: | CD117 |
| Application: | Flow cytometry |
| Clonality: | monoclonal |
| Clone: | 104D2 |
| Emission Maximum: | 780 nm |
| Excitation Maximum: | 650 nm, 750 nm |
| Field of Interest: | Immunophenotyping, Phosphorylation |
| Format/Fluorochrome: | APC-Cy7 |
| Isotype: | IgG1 |
| Laser: | Red |
| Regulatory Status: | CE IVD |
| Source Species: | Mouse |
| Target Species: | Human |
| Product number: | AP317312 |
CE IVD
| HLDA Workshop | HLDA VI—WS Code C-30 |
| Concentration Unit | µg/mL |
| Concentration | 25 |
| Quantity | 100 tests |
| Volume | 1.0 mL |
| Immunogen | MOLM-1 megakaryocytic cells |
| Background Information | CD117 (c-Kit) is a 145 kDa receptor tyrosine kinase that regulates cell proliferation, adhesion, chemotaxis, apoptosis and other cell processes. Mutations of CD117 can lead to growth and progression of tumors. After binding of its ligand, SCF (stem cell factor), CD117 is autophosphorylated on its intracellular domains and activated. CD117 is expressed on pluripotent hematopoietic progenitor cells, mast cells and various cancer cells, e.g. acute myeloid leukemia cells. |
| Antigen Distribution | CD117 (c-kit, SCFR) is a 145 kDa receptor tyrosine kinase expressed on pluripotent hematopoietic progenitor cells and mast cells. It regulates cell proliferation, adhesion, chemotaxis, apoptosis and other cell processes. After binding of its ligand, SCF (stem cell factor), CD117 is autophosphorylated on its intracellular domains and activated. |
| Usage | CE IVD usage Placeholder |
| Storage Buffer | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide and 0.2% (w/v) BSA. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
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